Therapy should be administered with caution, if whatsoever, to people who are mentally depressed, have suicidal tendencies, or background of drug abuse
pentobarbital will reduce the extent or effect of clarithromycin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
pentobarbital will lessen the extent or influence of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, insufficient efficacy or, probably, growth of a withdrawal syndrome in a very affected person who has formulated Actual physical dependence to fentanyl.
Contraindicated (one)pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lessen panobinostat stages by ~70% and produce remedy failure.
pentobarbital will minimize the level or effect of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Extended-term coadministration of robust CYP3A4 inducers with rolapitant may well noticeably lessen rolapitant efficacy.
pentobarbital will minimize the level or effect of tamoxifen by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.
Check Closely (one)pentobarbital will reduce the level or impact of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone could boost and may end up in most likely fatal respiratory depressionSerious - Use Alternate (1)hydrocodone, pentobarbital.
Watch Intently (1)pentobarbital will reduce the extent or result of cannabidiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or impact of nimodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.
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pentobarbital will lessen the extent or outcome of venetoclax by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or influence of irinotecan liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will minimize the extent or impact of carvedilol by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Monitor.
pentobarbital will lower the level or impact of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.